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Glucose Disposal Agents (GDA's) are supplements that are used to help control blood sugar and promote fat loss. Ketogenics Glucosatrol® takes a comprehensive and refined approach to blood sugar balance and nutrient partitioning and fat loss.

Today, we take a closer look at one of the ingredients in Glucosatrol: Berberine


Berberine is an alkaloid extracted from various plants used in traditional Chinese medicine. It's primarily used to reduce insulin resistance and improve biomarkers of type II diabetes such as fasting glucose and HbA1c.

** In June of 2023, people on social media started touting berberine as “Nature’s Ozempic.” Ozempic (the generic drug name is Semaglutide), so we felt it was important to mention this in the description of Berberine.

Ozempic, a drug used to treat diabetes, keeps gaining attention as celebrities, Elon Musk and TikTok influencers have admitted to taking it to lose weight and lose weight in a very short time frame. Ozempic and Semaglutide are part of a class of drugs called GLP-1 agonists, which mimic a hormone that helps reduce food intake and appetite.

While both berberine and GLP-1 agonists like Ozempic and Wegovy have some effects on weight, they work through different mechanisms. GLP-1 agonists mimic the action of a hormone called glucagon-like peptide-1 (GLP-1), which helps reduce food intake and appetite through the augmentation of insulin secretion, suppression of glucagon secretion, and deceleration of gastric emptying.”

Berberine is NOT like Ozempic or Nature's Ozempic. Berberine is not a drug nor does it come with the negative side effects of drugs.

Berberine promotes weight loss through different pathways, such as AMPK activation and improvements in insulin sensitivity.

A review of 12 studies in 2020 found that supplementing with berberine led to significant reductions in body weight, body mass index, and belly fat.

Berberine is one of the most well-known compounds among the diabetic and low carb community. In a study comparing Berberine to the drug Metformin, Berberine significantly decreased HbA1c levels in diabetic patients. The effect of decreasing HbA1c was comparable to that of Metformin. In addition, berberine decreased serum triglyceride and total cholesterol significantly whereas Metformin did not. HDL-C and LDL-C levels of patients treated with berberine were also reduced. Insulin sensitivity was enhanced by berberine as the HOMA-IR value was reduced by nearly 50%.

Berberine also enhances the action of the AMPK enzyme that we mentioned above.

Increased AMPK activity supports better insulin sensitivity and glucose uptake into muscle cells and is associated with longer lifespan and better health; AMPK causes a biochemical cascade that promotes fat oxidation, increases cellular stress defenses and autophagy, and decreases inflammation. Intermittent fasting and ketogenic diets are known to trigger autophagy.

The activation of the AMPK pathway has numerous physiological benefits:

Reduction of blood triglycerides
Reduction of body fat mass
Inhibiting excess fat synthesis and increased burning of stored fat
Improved glucose uptake in cells, lowering blood sugar
Increased numbers of new, healthy mitochondria
Increase of exercise endurance
Berberine is one of 14 powerful ingredients included in our top selling Glucose Disposal Agent product Glucosatrol.

Glucosatrol contains an extensive list of ingredients that support glucose disposal. Not only do these ingredients promote healthy blood sugar levels and insulin release, but they also optimize nutrient partitioning (what becomes of the calories that enter your body in food, how your body stores these nutrients).

To learn more about Glucosatrol click the link below.​


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